Title |
Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia
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Published in |
Molecular Neurodegeneration, January 2014
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DOI | 10.1186/1750-1326-9-5 |
Pubmed ID | |
Authors |
María S Marcora, Agata C Fernández-Gamba, Luz A Avendaño, Cecilia Rotondaro, Osvaldo L Podhajcer, Rubén Vidal, Laura Morelli, María F Ceriani, Eduardo M Castaño |
Abstract |
Familial British and Familial Danish dementias (FBD and FDD, respectively) are associated with mutations in the BRI2 gene. Processing of the mutated BRI2 protein leads to the accumulation in the brain of the 34-mer amyloid Bri (ABri) and amyloid Dan (ADan) peptides, accompanied by neurofibrillary tangles. Recently, transgenic mice successfully reproduced different aspects of FDD, while modeling of FBD in vivo has been more difficult. In this work we have modeled FBD and FDD in Drosophila and tested the hypothesis that ABri and ADan are differentially neurotoxic. |
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