Title |
Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma
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Published in |
BMC Cancer, January 2014
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DOI | 10.1186/1471-2407-14-11 |
Pubmed ID | |
Authors |
Jiayin Xie, Liang Zhang, Mengxia Li, Jia Du, Liwei Zhou, Senlin Yang, Linli Zeng, Zengpeng Li, Ge Wang, Dong Wang |
Abstract |
Melphalan resistance has been considered one of the major obstacles to improve outcomes in multiple myeloma (MM) therapy; unfortunately, the mechanistic details of this resistance remain unclear. Melphalan is a highly effective alkylating agent which causes many types of DNA lesions, including DNA base alkylation damage that is repaired by base excision repair (BER). We postulated that human apurinic/apyrimidinic endonuclease 1 (APE1), an essential BER enzyme, plays a vital role in acquired melphalan resistance. However, because APE1 is a multifunctional protein with redox activity and acetylation modification in addition to its major repair activity, the particular APE1 function that may play a more important role in melphalan resistance is unknown. |
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United States | 1 | 50% |
Demographic breakdown
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 13 | 100% |
Demographic breakdown
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Researcher | 2 | 15% |
Other | 1 | 8% |
Student > Master | 1 | 8% |
Student > Postgraduate | 1 | 8% |
Other | 0 | 0% |
Unknown | 2 | 15% |
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Nursing and Health Professions | 1 | 8% |
Other | 0 | 0% |
Unknown | 2 | 15% |