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BACE1 activity regulates cell surface contactin-2 levels

Overview of attention for article published in Molecular Neurodegeneration, January 2014
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Title
BACE1 activity regulates cell surface contactin-2 levels
Published in
Molecular Neurodegeneration, January 2014
DOI 10.1186/1750-1326-9-4
Pubmed ID
Authors

Vivek Gautam, Carla D’Avanzo, Matthias Hebisch, Dora M Kovacs, Doo Yeon Kim

Abstract

Although BACE1 is a major therapeutic target for Alzheimer's disease (AD), potential side effects of BACE1 inhibition are not well characterized. BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been characterized. Here we investigated BACE1-mediated cleavage of human contactin-2, a GPI-anchored cell adhesion molecule.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 22%
Student > Bachelor 10 20%
Researcher 8 16%
Student > Master 7 14%
Student > Doctoral Student 3 6%
Other 2 4%
Unknown 10 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 24%
Biochemistry, Genetics and Molecular Biology 9 18%
Neuroscience 9 18%
Medicine and Dentistry 4 8%
Chemistry 3 6%
Other 3 6%
Unknown 11 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2016.
All research outputs
#13,400,446
of 22,739,983 outputs
Outputs from Molecular Neurodegeneration
#656
of 845 outputs
Outputs of similar age
#162,569
of 304,788 outputs
Outputs of similar age from Molecular Neurodegeneration
#10
of 18 outputs
Altmetric has tracked 22,739,983 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 845 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,788 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.