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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The spleen in liver cirrhosis: revisiting an old enemy with novel targets
|
|---|---|
| Published in |
Journal of Translational Medicine, May 2017
|
| DOI | 10.1186/s12967-017-1214-8 |
| Pubmed ID | |
| Authors |
Liang Li, Mubing Duan, Weisan Chen, An Jiang, Xiaoming Li, Jun Yang, Zongfang Li |
| Abstract |
The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension. These splenic abnormalities correlate with and have been postulated to facilitate the progression of liver fibrosis to cirrhosis, although precise mechanisms remain poorly understood. In this review, we summarize the literature to highlight the mechanistic contributions of splenomegaly and hypersplenism to the development of liver cirrhosis, focusing on three key aspects: hepatic fibrogenesis, hepatic immune microenvironment dysregulation and liver regeneration. We conclude with a discussion of the possible therapeutic strategies for modulating splenic abnormalities, including the novel potential usage of nanomedicine in non-surgically targetting splenic disorders for the treatment of liver cirrhosis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 127 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 10% |
| Student > Master | 12 | 9% |
| Student > Ph. D. Student | 11 | 9% |
| Researcher | 10 | 8% |
| Other | 8 | 6% |
| Other | 18 | 14% |
| Unknown | 55 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 28% |
| Biochemistry, Genetics and Molecular Biology | 13 | 10% |
| Nursing and Health Professions | 5 | 4% |
| Agricultural and Biological Sciences | 5 | 4% |
| Neuroscience | 3 | 2% |
| Other | 8 | 6% |
| Unknown | 58 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2023.
All research outputs
#2,471,607
of 23,197,711 outputs
Outputs from Journal of Translational Medicine
#403
of 4,077 outputs
Outputs of similar age
#48,176
of 314,101 outputs
Outputs of similar age from Journal of Translational Medicine
#11
of 80 outputs
Altmetric has tracked 23,197,711 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,077 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,101 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.