Title |
Prediction of individual immune responsiveness to a candidate vaccine by a systems vaccinology approach
|
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Published in |
Journal of Translational Medicine, January 2014
|
DOI | 10.1186/1479-5876-12-11 |
Pubmed ID | |
Authors |
Annacarmen Petrizzo, Maria Tagliamonte, Maria Lina Tornesello, Franco M Buonaguro, Luigi Buonaguro |
Abstract |
We have previously shown that a candidate idiotype vaccine, based on the IGKV3-20 light chain protein, is able to induce activation of circulating antigen presenting cells (APCs) in both HCV-positive and HCV-negative subjects, with production of Th2-type cytokines. In addition, such a candidate idiotype vaccine induces an early gene expression pattern, characterized by the strong induction of an innate immune response, and a late pattern, characterized by a prevalent B cell response. Nonetheless, some HCV-positive individuals showed a complete lack of maturation of circulating APCs with low levels of cytokine production, strongly suggesting the possible identification of selective impairments in immune response in individual subjects. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Netherlands | 1 | 3% |
Unknown | 29 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 29% |
Student > Master | 4 | 13% |
Student > Bachelor | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Other | 2 | 6% |
Other | 2 | 6% |
Unknown | 8 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 29% |
Biochemistry, Genetics and Molecular Biology | 5 | 16% |
Medicine and Dentistry | 3 | 10% |
Immunology and Microbiology | 2 | 6% |
Engineering | 2 | 6% |
Other | 1 | 3% |
Unknown | 9 | 29% |