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The impact of human hyperekplexia mutations on glycine receptor structure and function

Overview of attention for article published in Molecular Brain, January 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

twitter
3 tweeters

Citations

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96 Dimensions

Readers on

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101 Mendeley
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Title
The impact of human hyperekplexia mutations on glycine receptor structure and function
Published in
Molecular Brain, January 2014
DOI 10.1186/1756-6606-7-2
Pubmed ID
Authors

Anna Bode, Joseph W Lynch

Abstract

Hyperekplexia is a rare neurological disorder characterized by neonatal hypertonia, exaggerated startle responses to unexpected stimuli and a variable incidence of apnoea, intellectual disability and delays in speech acquisition. The majority of motor defects are successfully treated by clonazepam. Hyperekplexia is caused by hereditary mutations that disrupt the functioning of inhibitory glycinergic synapses in neuromotor pathways of the spinal cord and brainstem. The human glycine receptor α1 and β subunits, which predominate at these synapses, are the major targets of mutations. International genetic screening programs, that together have analysed several hundred probands, have recently generated a clear picture of genotype-phenotype correlations and the prevalence of different categories of hyperekplexia mutations. Focusing largely on this new information, this review seeks to summarise the effects of mutations on glycine receptor structure and function and how these functional alterations lead to hyperekplexia.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 <1%
Sweden 1 <1%
Bangladesh 1 <1%
Unknown 98 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 21 21%
Student > Ph. D. Student 18 18%
Researcher 13 13%
Student > Master 11 11%
Student > Doctoral Student 7 7%
Other 19 19%
Unknown 12 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 26%
Medicine and Dentistry 20 20%
Biochemistry, Genetics and Molecular Biology 16 16%
Neuroscience 12 12%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 9 9%
Unknown 15 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2016.
All research outputs
#4,684,404
of 9,722,866 outputs
Outputs from Molecular Brain
#210
of 487 outputs
Outputs of similar age
#76,913
of 195,829 outputs
Outputs of similar age from Molecular Brain
#6
of 22 outputs
Altmetric has tracked 9,722,866 research outputs across all sources so far. This one has received more attention than most of these and is in the 50th percentile.
So far Altmetric has tracked 487 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.