Title |
Acid Evoked Thermal Hyperalgesia Involves Peripheral P2Y1 Receptor Mediated TRPV1 Phosphorylation in a Rodent Model of Thrombus Induced Ischemic Pain
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Published in |
Molecular Pain, January 2014
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DOI | 10.1186/1744-8069-10-2 |
Pubmed ID | |
Authors |
Soon-Gu Kwon, Dae-Hyun Roh, Seo-Yeon Yoon, Ji-Young Moon, Sheu-Ran Choi, Hoon-Seong Choi, Suk-Yun Kang, Ho-Jae Han, Alvin J Beitz, Seog Bae Oh, Jang-Hern Lee |
Abstract |
We previously developed a thrombus-induced ischemic pain (TIIP) animal model, which was characterized by chronic bilateral mechanical allodynia without thermal hyperalgesia (TH). On the other hand we had shown that intraplantar injection of acidic saline facilitated ATP-induced pain, which did result in the induction of TH in normal rats. Because acidic pH and increased ATP are closely associated with ischemic conditions, this study is designed to: (1) examine whether acidic saline injection into the hind paw causes the development of TH in TIIP, but not control, animals; and (2) determine which peripheral mechanisms are involved in the development of this TH. |
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