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p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis

Overview of attention for article published in Molecular Cancer, April 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
46 Mendeley
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Title
p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis
Published in
Molecular Cancer, April 2015
DOI 10.1186/s12943-015-0354-9
Pubmed ID
Authors

Sahar S Bhat, Deepak Anand, Firdous A Khanday

Abstract

p66Shc, a member of the ShcA (Src homologous- collagen homologue) adaptor protein family, is one of the three isoforms of this family along with p46Shc and p52Shc. p66Shc, a 66 kDa protein is different from the other isoforms of the ShcA family. p66Shc is the longest isoform of the ShcA family. p66Shc has an additional CH domain at the N-terminal, called the CH2 domain, which is not not present in the other isoforms. This CH2 domain contains a very crucial S36 residue which is phosphorylated in response to oxidative stress and plays a role in apoptosis. Whereas p52Shc and p46Shc are ubiquitously expressed, p66Shc shows constrained expression. This adaptor protein has been shown to be involved in mediating and executing the post effects of oxidative stress and increasing body of evidence is pinpointing to its role in carcinogenesis as well. It shows proto-oncogenic as well as pro-apoptotic properties. This multitasking protein is involved in regulating different networks of cell signaling. On one hand it shows an increased expression profile in different cancers, has a positive role in cell proliferation and migration, whereas on the other hand it promotes apoptosis under oxidative stress conditions by acting as a sensor of ROS (Reactive Oxygen Species). This paradoxical role of p66Shc could be attributed to its involvement in ROS production, as ROS is known to both induce cell proliferation as well as apoptosis. p66Shc by regulating intracellular ROS levels plays a crucial role in regulating longevity and cell senescence. These multi-faceted properties of p66Shc make it a perfect candidate protein for further studies in various cancers and aging related diseases. p66Shc can be targeted in terms of it being used as a possible therapeutic target in various diseases. This review focuses on p66Shc and highlights its role in promoting apoptosis via different cell signaling networks, its role in cell proliferation, along with its presence and role in different forms of cancers.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 24%
Student > Bachelor 7 15%
Researcher 7 15%
Student > Master 5 11%
Student > Doctoral Student 1 2%
Other 3 7%
Unknown 12 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 28%
Agricultural and Biological Sciences 7 15%
Medicine and Dentistry 2 4%
Design 2 4%
Neuroscience 2 4%
Other 5 11%
Unknown 15 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2017.
All research outputs
#2,910,107
of 10,867,257 outputs
Outputs from Molecular Cancer
#188
of 958 outputs
Outputs of similar age
#90,825
of 264,020 outputs
Outputs of similar age from Molecular Cancer
#3
of 9 outputs
Altmetric has tracked 10,867,257 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 958 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.