Title |
A Putative Relay Circuit Providing Low-Threshold Mechanoreceptive Input to Lamina I Projection Neurons via Vertical Cells in Lamina II of the Rat Dorsal Horn
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Published in |
Molecular Pain, January 2014
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DOI | 10.1186/1744-8069-10-3 |
Pubmed ID | |
Authors |
Toshiharu Yasaka, Sheena YX Tiong, Erika Polgár, Masahiko Watanabe, Eiichi Kumamoto, John S Riddell, Andrew J Todd |
Abstract |
Lamina I projection neurons respond to painful stimuli, and some are also activated by touch or hair movement. Neuropathic pain resulting from peripheral nerve damage is often associated with tactile allodynia (touch-evoked pain), and this may result from increased responsiveness of lamina I projection neurons to non-noxious mechanical stimuli. It is thought that polysynaptic pathways involving excitatory interneurons can transmit tactile inputs to lamina I projection neurons, but that these are normally suppressed by inhibitory interneurons. Vertical cells in lamina II provide a potential route through which tactile stimuli can activate lamina I projection neurons, since their dendrites extend into the region where tactile afferents terminate, while their axons can innervate the projection cells. The aim of this study was to determine whether vertical cell dendrites were contacted by the central terminals of low-threshold mechanoreceptive primary afferents. |
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