Title |
Neuregulin-1 attenuates mortality associated with experimental cerebral malaria
|
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Published in |
Journal of Neuroinflammation, January 2014
|
DOI | 10.1186/1742-2094-11-9 |
Pubmed ID | |
Authors |
Wesley Solomon, Nana O Wilson, Leonard Anderson, Sidney Pitts, John Patrickson, Mingli Liu, Byron D Ford, Jonathan K Stiles |
Abstract |
Cerebral Malaria (CM) is a diffuse encephalopathy caused by Plasmodium falciparum infection. Despite availability of antimalarial drugs, CM-associated mortality remains high at approximately 30% and a subset of survivors develop neurological and cognitive disabilities. While antimalarials are effective at clearing Plasmodium parasites they do little to protect against CM pathophysiology and parasite-induced brain inflammation that leads to seizures, coma and long-term neurological sequelae in CM patients. Thus, there is urgent need to explore therapeutics that can reduce or prevent CM pathogenesis and associated brain inflammation to improve survival. Neuregulin-1 (NRG-1) is a neurotrophic growth factor shown to protect against brain injury associated with acute ischemic stroke (AIS) and neurotoxin exposure. However, this drug has not been tested against CM-associated brain injury. Since CM-associated brain injuries and AIS share similar pathophysiological features, we hypothesized that NRG-1 will reduce or prevent neuroinflammation and brain damage as well as improve survival in mice with late-stage experimental cerebral malaria (ECM). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Australia | 1 | 2% |
Unknown | 63 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 13 | 20% |
Student > Ph. D. Student | 12 | 18% |
Student > Master | 11 | 17% |
Researcher | 6 | 9% |
Other | 4 | 6% |
Other | 8 | 12% |
Unknown | 11 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 19 | 29% |
Agricultural and Biological Sciences | 7 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
Nursing and Health Professions | 3 | 5% |
Chemistry | 3 | 5% |
Other | 13 | 20% |
Unknown | 14 | 22% |