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Atropisomeric determination of chiral hydroxylated metabolites of polychlorinated biphenyls using HPLC-MS

Overview of attention for article published in BMC Chemistry, December 2013
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Title
Atropisomeric determination of chiral hydroxylated metabolites of polychlorinated biphenyls using HPLC-MS
Published in
BMC Chemistry, December 2013
DOI 10.1186/1752-153x-7-183
Pubmed ID
Authors

Guangshu Zhai, Xianai Wu, Hans-Joachim Lehmler, Jerald L Schnoor

Abstract

Polychlorinated biphenyls (PCBs) are a group of environmental persistent organic pollutants, which can be metabolized into a series of metabolites, including hydroxylated metabolites (OH-PCBs) in biota. Nineteen of 209 PCB congeners can form chiral stable isomers. However, atropisomeric determination of the hydroxylated metabolites of these chiral PCBs has never been reported by LC methods. In this work, a novel HPLC-MS method was developed to detect five chiral OH-PCBs (4OH-PCB91, 5OH-PCB91, 4OH-PCB95, 5OH-PCB95 and 5OH-PCB149) using HPLC-MS without a derivatization step.

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The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 23%
Student > Bachelor 2 15%
Researcher 2 15%
Professor 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 3 23%
Readers by discipline Count As %
Engineering 4 31%
Agricultural and Biological Sciences 3 23%
Chemistry 2 15%
Environmental Science 1 8%
Unknown 3 23%