Title |
Medication overuse headache: a critical review of end points in recent follow-up studies
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Published in |
The Journal of Headache and Pain, May 2010
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DOI | 10.1007/s10194-010-0221-4 |
Pubmed ID | |
Authors |
Knut Hagen, Rigmor Jensen, Magne Geir Bøe, Lars Jacob Stovner |
Abstract |
No guidelines for performing and presenting the results of studies on patients with medication overuse headache (MOH) exist. The aim of this study was to review long-term outcome measures in follow-up studies published in 2006 or later. We included MOH studies with >6 months duration presenting a minimum of one predefined end point. In total, nine studies were identified. The 1,589 MOH patients (22% men) had an overall mean frequency of 25.3 headache days/month at baseline. Headache days/month at the end of follow-up was reported in six studies (mean 13.8 days/month). The decrease was more pronounced for studies including patients with migraine only (-14.6 days/month) compared to studies with the original diagnoses of migraine and tension-type headache (-9.2 days/month). Six studies reported relapse rate (mean of 26%) and/or responder rate (mean of 28%). Medication days/month and change in headache index at the end of follow-up were reported in only one and two of nine studies, respectively. The present review demonstrated a lack of uniform end points used in recently published follow-up studies. Guidelines for presenting follow-up data on MOH are needed and we propose end points such as headache days/month, medication days/month, relapse rate and responder rate defined as ≥50% reduction of headache frequency and/or headache index from baseline. |
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Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 30% |
Student > Master | 5 | 17% |
Student > Bachelor | 4 | 13% |
Other | 4 | 13% |
Researcher | 3 | 10% |
Other | 0 | 0% |
Unknown | 5 | 17% |
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Computer Science | 1 | 3% |
Other | 0 | 0% |
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