Title |
Difference in mobilization of progenitor cells after myocardial infarction in smoking versus non-smoking patients: insights from the BONAMI trial
|
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Published in |
Stem Cell Research & Therapy, December 2013
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DOI | 10.1186/scrt382 |
Pubmed ID | |
Authors |
Guillaume Lamirault, Sophie Susen, Virginie Forest, Caroline Hemont, Angelo Parini, Philippe Le Corvoisier, Christophe Piot, Marie-Jeanne Richard, Béatrice Delasalle, Hélène Rouard, Catherine Sportouch, Virginie Persoons, Eric Van Belle, Jérôme Roncalli, Patricia Lemarchand |
Abstract |
Although autologous bone marrow cell (BMC) therapy has emerged as a promising treatment for acute myocardial infarction (AMI), trials reported mixed results. In the BONAMI trial, active smoking reduced cardiac function recovery after reperfused AMI. Therefore, we hypothesized that variability in the functionality of BMCs retrieved from patients with cardiovascular risk factors may partly explain these mixed results. We investigated the characteristics of progenitor cells in active smokers and non-smokers with AMI and their potential impact on BMC therapy efficacy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 23% |
Researcher | 6 | 12% |
Student > Ph. D. Student | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Student > Master | 4 | 8% |
Other | 8 | 15% |
Unknown | 13 | 25% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 6 | 12% |
Unknown | 14 | 27% |