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L-mimosine and hypoxia can increase angiogenin production in dental pulp-derived cells

Overview of attention for article published in BMC Oral Health, May 2017
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  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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4 tweeters

Citations

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10 Dimensions

Readers on

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43 Mendeley
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Title
L-mimosine and hypoxia can increase angiogenin production in dental pulp-derived cells
Published in
BMC Oral Health, May 2017
DOI 10.1186/s12903-017-0373-6
Pubmed ID
Authors

Klara Janjić, Michael Edelmayer, Andreas Moritz, Hermann Agis

Abstract

Angiogenin is a key molecule in the healing process which has been successfully applied in the field of regenerative medicine. The role of angiogenin in dental pulp regeneration is unclear. Here we aimed to reveal the impact of the hypoxia mimetic agent L-mimosine (L-MIM) and hypoxia on angiogenin in the dental pulp. Human dental pulp-derived cells (DPC) were cultured in monolayer and spheroid cultures and treated with L-MIM or hypoxia. In addition, tooth slice organ cultures were applied to mimic the pulp-dentin complex. We measured angiogenin mRNA and protein levels using qPCR and ELISA, respectively. Inhibitor studies with echinomycin were performed to reveal the role of hypoxia-inducible factor (HIF)-1 signaling. Both, L-MIM and hypoxia increased the production of angiogenin at the protein level in monolayer cultures of DPC, while the increase at the mRNA level did not reach the level of significance. The increase of angiogenin in response to treatment with L-MIM or hypoxia was reduced by echinomycin. In spheroid cultures, L-MIM increased angiogenin at protein levels while the effect of hypoxia was not significant. Angiogenin was also expressed and released in tooth slice organ cultures under normoxic and hypoxic conditions and in the presence of L-MIM. L-MIM and hypoxia modulate production of angiogenin via HIF-1 differentially and the response depends on the culture model. Given the role of angiogenin in regeneration the here presented results are of high relevance for pre-conditioning approaches for cell therapy and tissue engineering in the field of regenerative endodontics.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 19%
Student > Doctoral Student 5 12%
Student > Postgraduate 4 9%
Student > Master 4 9%
Student > Bachelor 3 7%
Other 6 14%
Unknown 13 30%
Readers by discipline Count As %
Medicine and Dentistry 13 30%
Agricultural and Biological Sciences 6 14%
Biochemistry, Genetics and Molecular Biology 3 7%
Nursing and Health Professions 1 2%
Chemical Engineering 1 2%
Other 2 5%
Unknown 17 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2017.
All research outputs
#13,862,088
of 22,977,819 outputs
Outputs from BMC Oral Health
#589
of 1,488 outputs
Outputs of similar age
#165,745
of 313,676 outputs
Outputs of similar age from BMC Oral Health
#8
of 21 outputs
Altmetric has tracked 22,977,819 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,488 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,676 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.