Title |
Gene expression and nucleotide composition are associated with genic methylation level in Oryza sativa
|
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Published in |
BMC Bioinformatics, January 2014
|
DOI | 10.1186/1471-2105-15-23 |
Pubmed ID | |
Authors |
Eran Elhaik, Matteo Pellegrini, Tatiana V Tatarinova |
Abstract |
The methylation of cytosines at CpG dinucleotides, which plays an important role in gene expression regulation, is one of the most studied epigenetic modifications. Thus far, the detection of DNA methylation has been determined mostly by experimental methods, which are not only prone to bench effects and artifacts but are also time-consuming, expensive, and cannot be easily scaled up to many samples. It is therefore useful to develop computational prediction methods for DNA methylation. Our previous studies highlighted the existence of correlations between the GC content of the third codon position (GC₃), methylation, and gene expression. We thus designed a model to predict methylation in Oryza sativa based on genomic sequence features and gene expression data. |
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Geographical breakdown
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Mexico | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 46 | 100% |
Demographic breakdown
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Researcher | 11 | 24% |
Professor > Associate Professor | 7 | 15% |
Student > Ph. D. Student | 6 | 13% |
Student > Master | 5 | 11% |
Student > Bachelor | 2 | 4% |
Other | 7 | 15% |
Unknown | 8 | 17% |
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Computer Science | 5 | 11% |
Mathematics | 1 | 2% |
Psychology | 1 | 2% |
Other | 4 | 9% |
Unknown | 10 | 22% |