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The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions

Overview of attention for article published in Retrovirology, January 2014
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

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7 X users

Citations

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31 Dimensions

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43 Mendeley
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Title
The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions
Published in
Retrovirology, January 2014
DOI 10.1186/1742-4690-11-9
Pubmed ID
Authors

Ayumi Kudoh, Shoukichi Takahama, Tatsuya Sawasaki, Hirotaka Ode, Masaru Yokoyama, Akiko Okayama, Akiyo Ishikawa, Kei Miyakawa, Satoko Matsunaga, Hirokazu Kimura, Wataru Sugiura, Hironori Sato, Hisashi Hirano, Shigeo Ohno, Naoki Yamamoto, Akihide Ryo

Abstract

Human immunodeficiency virus type 1 (HIV-1) Gag is the main structural protein that mediates the assembly and release of virus-like particles (VLPs) from an infected cell membrane. The Gag C-terminal p6 domain contains short sequence motifs that facilitate virus release from the plasma membrane and mediate incorporation of the viral Vpr protein. Gag p6 has also been found to be phosphorylated during HIV-1 infection and this event may affect virus replication. However, the kinase that directs the phosphorylation of Gag p6 toward virus replication remains to be identified. In our present study, we identified this kinase using a proteomic approach and further delineate its role in HIV-1 replication.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Germany 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Researcher 10 23%
Student > Bachelor 4 9%
Student > Master 3 7%
Student > Doctoral Student 2 5%
Other 6 14%
Unknown 7 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 26%
Agricultural and Biological Sciences 9 21%
Immunology and Microbiology 5 12%
Medicine and Dentistry 3 7%
Computer Science 3 7%
Other 4 9%
Unknown 8 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2014.
All research outputs
#6,876,051
of 22,741,406 outputs
Outputs from Retrovirology
#366
of 1,105 outputs
Outputs of similar age
#82,611
of 305,705 outputs
Outputs of similar age from Retrovirology
#10
of 39 outputs
Altmetric has tracked 22,741,406 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,105 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,705 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.