Title |
Adiponectin, chemerin, cytokines, and dipeptidyl peptidase 4 are released from human adipose tissue in a depot-dependent manner: an in vitro system including human serum albumin
|
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Published in |
BMC Endocrine Disorders, January 2014
|
DOI | 10.1186/1472-6823-14-7 |
Pubmed ID | |
Authors |
Henrik Svensson, Birgitta Odén, Staffan Edén, Malin Lönn |
Abstract |
Adipose tissue (AT) contributes to metabolic dysfunction through imbalanced production of adipokines, including cytokines. Visceral AT in particular is associated with metabolic disorders, indicating a specific secretory status. The relative significance of different human AT depots in adipokine release is not fully known. Further, previous in vitro systems usually included medium containing bovine serum albumin (BSA), which may induce cytokine release. Our aim was to compare release of a number of adipokines/cytokines - all implicated in insulin resistance - from human subcutaneous and visceral AT in a short-term incubation system minimizing cytokine induction and including repeated measurements during 24 h. A prerequisite was to evaluate a potential alternative to BSA in the incubation medium. |
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Mendeley readers
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Researcher | 4 | 10% |
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Professor > Associate Professor | 3 | 7% |
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