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Innate immunity and monocyte-macrophage activation in atherosclerosis

Overview of attention for article published in Journal of Inflammation, April 2011
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1 tweeter

Citations

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105 Dimensions

Readers on

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239 Mendeley
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Title
Innate immunity and monocyte-macrophage activation in atherosclerosis
Published in
Journal of Inflammation, April 2011
DOI 10.1186/1476-9255-8-9
Pubmed ID
Authors

Joseph Shalhoub, Mika A Falck-Hansen, Alun H Davies, Claudia Monaco

Abstract

Innate inflammation is a hallmark of both experimental and human atherosclerosis. The predominant innate immune cell in the atherosclerotic plaque is the monocyte-macrophage. The behaviour of this cell type within the plaque is heterogeneous and depends on the recruitment of diverse monocyte subsets. Furthermore, the plaque microenvironment offers polarisation and activation signals which impact on phenotype. Microenvironmental signals are sensed through pattern recognition receptors, including toll-like and NOD-like receptors - the latter of which are components of the inflammasome - thus dictating macrophage behaviour and outcome in atherosclerosis. Recently cholesterol crystals and modified lipoproteins have been recognised as able to directly engage these pattern recognition receptors. The convergent role of such pathways in terms of macrophage activation is discussed in this review.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 239 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 2%
Germany 2 <1%
United States 2 <1%
Canada 2 <1%
Brazil 1 <1%
Ireland 1 <1%
Indonesia 1 <1%
Russia 1 <1%
Belgium 1 <1%
Other 2 <1%
Unknown 221 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 53 22%
Researcher 42 18%
Student > Master 32 13%
Professor > Associate Professor 17 7%
Student > Doctoral Student 15 6%
Other 58 24%
Unknown 22 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 96 40%
Medicine and Dentistry 57 24%
Biochemistry, Genetics and Molecular Biology 22 9%
Immunology and Microbiology 16 7%
Pharmacology, Toxicology and Pharmaceutical Science 6 3%
Other 12 5%
Unknown 30 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2014.
All research outputs
#3,062,394
of 4,507,509 outputs
Outputs from Journal of Inflammation
#83
of 125 outputs
Outputs of similar age
#80,199
of 122,227 outputs
Outputs of similar age from Journal of Inflammation
#10
of 10 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 125 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,227 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.