Title |
Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms
|
---|---|
Published in |
BMC Genomics, January 2014
|
DOI | 10.1186/1471-2164-15-54 |
Pubmed ID | |
Authors |
Pablo Ivan Pereira Ramos, Renata Christina Picão, Luiz Gonzaga Paula de Almeida, Nicholas Costa B Lima, Raquel Girardello, Ana Carolina P Vivan, Danilo E Xavier, Fernando G Barcellos, Marsileni Pelisson, Eliana C Vespero, Claudine Médigue, Ana Tereza Ribeiro de Vasconcelos, Ana Cristina Gales, Marisa Fabiana Nicolás |
Abstract |
Klebsiella pneumoniae is an important opportunistic pathogen associated with nosocomial and community-acquired infections. A wide repertoire of virulence and antimicrobial resistance genes is present in K. pneumoniae genomes, which can constitute extra challenges in the treatment of infections caused by some strains. K. pneumoniae Kp13 is a multidrug-resistant strain responsible for causing a large nosocomial outbreak in a teaching hospital located in Southern Brazil. Kp13 produces K. pneumoniae carbapenemase (KPC-2) but is unrelated to isolates belonging to ST 258 and ST 11, the main clusters associated with the worldwide dissemination of KPC-producing K. pneumoniae. In this report, we perform a genomic comparison between Kp13 and each of the following three K. pneumoniae genomes: MGH 78578, NTUH-K2044 and 342. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 5 | 3% |
India | 2 | 1% |
Sudan | 1 | <1% |
France | 1 | <1% |
Portugal | 1 | <1% |
Belgium | 1 | <1% |
Denmark | 1 | <1% |
United States | 1 | <1% |
Unknown | 171 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 21% |
Researcher | 34 | 18% |
Student > Master | 31 | 17% |
Student > Doctoral Student | 12 | 7% |
Student > Bachelor | 11 | 6% |
Other | 26 | 14% |
Unknown | 32 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 49 | 27% |
Biochemistry, Genetics and Molecular Biology | 32 | 17% |
Medicine and Dentistry | 25 | 14% |
Immunology and Microbiology | 13 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 12 | 7% |
Unknown | 47 | 26% |