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Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells

Overview of attention for article published in Lipids in Health and Disease, March 2009
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Title
Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells
Published in
Lipids in Health and Disease, March 2009
DOI 10.1186/1476-511x-8-11
Pubmed ID
Authors

Tiina Solakivi, Tarja Kunnas, Satu Kärkkäinen, Olli Jaakkola, Seppo T Nikkari

Abstract

Dietary fatty acids may modulate inflammation in macrophages of the atherosclerotic plaque, affecting its stability. The n-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA) generally promotes inflammation, while the PUFAs of the n-3 series eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) are considered anti-inflammatory. We determined how these PUFAs influence MMP-9 expression and secretion by the human monocytic cell line (MonoMac 6) at baseline and after 24-hour exposure. MMP-9 protein was measured by zymography and relative levels of MMP-9 mRNA were determined using quantitative real time PCR.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 11%
Unknown 16 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 33%
Researcher 3 17%
Student > Master 1 6%
Student > Bachelor 1 6%
Student > Doctoral Student 1 6%
Other 2 11%
Unknown 4 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 28%
Biochemistry, Genetics and Molecular Biology 3 17%
Medicine and Dentistry 3 17%
Neuroscience 1 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 0 0%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2014.
All research outputs
#20,217,843
of 22,741,406 outputs
Outputs from Lipids in Health and Disease
#1,196
of 1,441 outputs
Outputs of similar age
#88,623
of 92,434 outputs
Outputs of similar age from Lipids in Health and Disease
#3
of 3 outputs
Altmetric has tracked 22,741,406 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,441 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,434 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.