Title |
Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells
|
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Published in |
Lipids in Health and Disease, March 2009
|
DOI | 10.1186/1476-511x-8-11 |
Pubmed ID | |
Authors |
Tiina Solakivi, Tarja Kunnas, Satu Kärkkäinen, Olli Jaakkola, Seppo T Nikkari |
Abstract |
Dietary fatty acids may modulate inflammation in macrophages of the atherosclerotic plaque, affecting its stability. The n-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA) generally promotes inflammation, while the PUFAs of the n-3 series eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) are considered anti-inflammatory. We determined how these PUFAs influence MMP-9 expression and secretion by the human monocytic cell line (MonoMac 6) at baseline and after 24-hour exposure. MMP-9 protein was measured by zymography and relative levels of MMP-9 mRNA were determined using quantitative real time PCR. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 11% |
Unknown | 16 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 33% |
Researcher | 3 | 17% |
Student > Master | 1 | 6% |
Student > Bachelor | 1 | 6% |
Student > Doctoral Student | 1 | 6% |
Other | 2 | 11% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
---|---|---|
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 5 | 28% |