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In vivo and in situ programming of tumor immunity by combining oncolytics and PD-1 immune checkpoint blockade

Overview of attention for article published in Experimental Hematology & Oncology, May 2017
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3 X users

Citations

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8 Dimensions

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12 Mendeley
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Title
In vivo and in situ programming of tumor immunity by combining oncolytics and PD-1 immune checkpoint blockade
Published in
Experimental Hematology & Oncology, May 2017
DOI 10.1186/s40164-017-0075-4
Pubmed ID
Authors

Eric Bartee, Zihai Li

Abstract

Blockade of the programmed cell death protein 1 (PD1) pathway is clinically effective against human cancers. Although multiple types of malignancies have been shown to respond to PD1 agents, only a small percentage of patients typically benefit from this treatment. In addition, PD1 therapy often causes serious immune-related adverse events. A recent study demonstrated that local, intra-tumoral, administration of modified oncolytic myxoma virus which expresses a truncated version of the PD1 protein resulted in both increased efficacy and reduced toxicity in a clinically relevant melanoma model.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 42%
Researcher 3 25%
Student > Doctoral Student 1 8%
Student > Master 1 8%
Student > Postgraduate 1 8%
Other 0 0%
Unknown 1 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 33%
Pharmacology, Toxicology and Pharmaceutical Science 2 17%
Immunology and Microbiology 2 17%
Medicine and Dentistry 1 8%
Unknown 3 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2017.
All research outputs
#13,202,765
of 22,977,819 outputs
Outputs from Experimental Hematology & Oncology
#94
of 298 outputs
Outputs of similar age
#153,356
of 313,673 outputs
Outputs of similar age from Experimental Hematology & Oncology
#3
of 6 outputs
Altmetric has tracked 22,977,819 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 298 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,673 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.