Title |
A BAC clone fingerprinting approach to the detection of human genome rearrangements
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Published in |
Genome Biology, October 2007
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DOI | 10.1186/gb-2007-8-10-r224 |
Pubmed ID | |
Authors |
Martin Krzywinski, Ian Bosdet, Carrie Mathewson, Natasja Wye, Jay Brebner, Readman Chiu, Richard Corbett, Matthew Field, Darlene Lee, Trevor Pugh, Stas Volik, Asim Siddiqui, Steven Jones, Jacquie Schein, Collin Collins, Marco Marra |
Abstract |
We present a method, called fingerprint profiling (FPP), that uses restriction digest fingerprints of bacterial artificial chromosome clones to detect and classify rearrangements in the human genome. The approach uses alignment of experimental fingerprint patterns to in silico digests of the sequence assembly and is capable of detecting micro-deletions (1-5 kb) and balanced rearrangements. Our method has compelling potential for use as a whole-genome method for the identification and characterization of human genome rearrangements. |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Sweden | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
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Researcher | 4 | 24% |
Student > Master | 3 | 18% |
Other | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
Student > Bachelor | 2 | 12% |
Other | 2 | 12% |
Unknown | 2 | 12% |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 0 | 0% |
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