Title |
The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
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Published in |
Journal of Translational Medicine, January 2014
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DOI | 10.1186/1479-5876-12-16 |
Pubmed ID | |
Authors |
Yu Gu, Tianxiang Chen, Elena López, Weizhu Wu, Xiangdong Wang, Jiang Cao, Lisong Teng |
Abstract |
Estrogen receptor-alpha36 (ER-α36) is a new isoform of estrogen receptors without transcriptional activation domains of the classical ER-α(ER - α66). ER-α36 is mainly located in cytoplasm and plasma membrane. ER-α36 mediates non-genomic signaling and is involved in genomic signaling of other ERs. Recently ER-α36 is found to play a critical role in the development of estrogen-dependent cancers and endocrine resistance of breast cancer. The present article overviews and updates the biological nature and function of ER-α36, potential interaction of ER-α36 with other estrogen receptors and growth factor receptors, intracellular signaling pathways, potential mechanism by which ER-α36 may play an important role in the development of tumor resistance to endocrine therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hungary | 1 | 2% |
Switzerland | 1 | 2% |
Unknown | 44 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 20% |
Student > Bachelor | 5 | 11% |
Researcher | 5 | 11% |
Student > Doctoral Student | 4 | 9% |
Lecturer | 4 | 9% |
Other | 8 | 17% |
Unknown | 11 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 28% |
Biochemistry, Genetics and Molecular Biology | 10 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
Medicine and Dentistry | 4 | 9% |
Chemistry | 2 | 4% |
Other | 2 | 4% |
Unknown | 11 | 24% |