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Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity

Overview of attention for article published in Molecular Pain, January 2014
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  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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65 Mendeley
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Title
Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity
Published in
Molecular Pain, January 2014
DOI 10.1186/1744-8069-10-5
Pubmed ID
Authors

Byeongjun Lee, Hawon Cho, Jooyoung Jung, Young Duk Yang, Dong-Jin Yang, Uhtaek Oh

Abstract

Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli. The molecular mechanism based on the pain hypersensitivity is associated with changes in many of ion channels in dorsal-root ganglion (DRG) neurons. Anoctamin 1 (ANO1/TMEM16A), a Ca2+ activated chloride channel is highly visible in small DRG neurons and responds to heat. Mice with an abolished function of ANO1 in DRG neurons demonstrated attenuated pain-like behaviors when exposed to noxious heat, suggesting a role in acute thermal nociception. In this study, we further examined the function of ANO1 in mediating inflammation- or injury-induced hyperalgesia or allodynia.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 2%
Germany 1 2%
Unknown 63 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 31%
Student > Bachelor 7 11%
Researcher 7 11%
Student > Master 7 11%
Other 5 8%
Other 11 17%
Unknown 8 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 31%
Medicine and Dentistry 10 15%
Neuroscience 10 15%
Biochemistry, Genetics and Molecular Biology 7 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Other 2 3%
Unknown 12 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2014.
All research outputs
#14,473,281
of 25,373,627 outputs
Outputs from Molecular Pain
#268
of 669 outputs
Outputs of similar age
#169,130
of 319,280 outputs
Outputs of similar age from Molecular Pain
#19
of 58 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,280 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.