Title |
Lung protection during non-invasive synchronized assist versus volume control in rabbits
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Published in |
Critical Care, January 2014
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DOI | 10.1186/cc13706 |
Pubmed ID | |
Authors |
Lucia Mirabella, Giacomo Grasselli, Jack J Haitsma, Haibo Zhang, Arthur S Slutsky, Christer Sinderby, Jennifer Beck |
Abstract |
Experimental work provides insight into potential lung protective strategies. The objective of this study was to evaluate markers of ventilator-induced lung injury after two different ventilation approaches: (1) a "conventional" lung-protective strategy (volume control (VC) with low tidal volume, positive end-expiratory pressure (PEEP) and paralysis), (2) a physiological approach with spontaneous breathing, permitting synchrony, variability and a liberated airway. For this, we used non-invasive Neurally Adjusted Ventilatory Assist (NIV-NAVA), with the hypothesis that liberation of upper airways and the ventilator's integration with lung protective reflexes would be equally lung protective. |
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United States | 1 | 25% |
Spain | 1 | 25% |
Canada | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
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Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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Professor | 5 | 12% |
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Unknown | 10 | 24% |
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Unknown | 10 | 24% |