Title |
Combined analysis of chromosomal instabilities and gene expression for colon cancer progression inference
|
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Published in |
Journal of Clinical Bioinformatics, January 2014
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DOI | 10.1186/2043-9113-4-2 |
Pubmed ID | |
Authors |
Claudia Cava, Italo Zoppis, Manuela Gariboldi, Isabella Castiglioni, Giancarlo Mauri, Marco Antoniotti |
Abstract |
Copy number alterations (CNAs) represent an important component of genetic variations. Such alterations are related with certain type of cancer including those of the pancreas, colon, and breast, among others. CNAs have been used as biomarkers for cancer prognosis in multiple studies, but few works report on the relation of CNAs with the disease progression. Moreover, most studies do not consider the following two important issues. (I) The identification of CNAs in genes which are responsible for expression regulation is fundamental in order to define genetic events leading to malignant transformation and progression. (II) Most real domains are best described by structured data where instances of multiple types are related to each other in complex ways. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 32% |
Student > Bachelor | 3 | 16% |
Professor > Associate Professor | 3 | 16% |
Student > Ph. D. Student | 3 | 16% |
Lecturer | 1 | 5% |
Other | 3 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Computer Science | 5 | 26% |
Agricultural and Biological Sciences | 5 | 26% |
Biochemistry, Genetics and Molecular Biology | 3 | 16% |
Engineering | 2 | 11% |
Physics and Astronomy | 1 | 5% |
Other | 3 | 16% |