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Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in…

Overview of attention for article published in Biology Direct, October 2009
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Title
Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea
Published in
Biology Direct, October 2009
DOI 10.1186/1745-6150-4-39
Pubmed ID
Authors

Fabian Blombach, Kira S Makarova, Jeannette Marrero, Bettina Siebers, Eugene V Koonin, John van der Oost

Abstract

One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA polymerase II with respect to the subunit composition. Here we identify archaeal orthologs of the eukaryotic RNA polymerase III subunit RPC34. Genome context analysis supports a function of this archaeal protein in the transcription of non-coding RNAs. These findings suggest that functional separation of RNA polymerases for protein-coding genes and non-coding RNAs might predate the origin of the Eukaryotes.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 4%
Spain 1 2%
Netherlands 1 2%
Brazil 1 2%
Unknown 47 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 29%
Student > Ph. D. Student 12 23%
Student > Master 7 13%
Professor > Associate Professor 3 6%
Professor 3 6%
Other 6 12%
Unknown 6 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 58%
Biochemistry, Genetics and Molecular Biology 7 13%
Immunology and Microbiology 2 4%
Computer Science 1 2%
Unspecified 1 2%
Other 2 4%
Unknown 9 17%