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Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

Overview of attention for article published in Biology Direct, July 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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2 X users
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28 patents
wikipedia
3 Wikipedia pages

Citations

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390 Dimensions

Readers on

mendeley
759 Mendeley
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1 CiteULike
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Title
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
Published in
Biology Direct, July 2011
DOI 10.1186/1745-6150-6-38
Pubmed ID
Authors

Kira S Makarova, L Aravind, Yuri I Wolf, Eugene V Koonin

Abstract

The CRISPR-Cas adaptive immunity systems that are present in most Archaea and many Bacteria function by incorporating fragments of alien genomes into specific genomic loci, transcribing the inserts and using the transcripts as guide RNAs to destroy the genome of the cognate virus or plasmid. This RNA interference-like immune response is mediated by numerous, diverse and rapidly evolving Cas (CRISPR-associated) proteins, several of which form the Cascade complex involved in the processing of CRISPR transcripts and cleavage of the target DNA. Comparative analysis of the Cas protein sequences and structures led to the classification of the CRISPR-Cas systems into three Types (I, II and III).

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 759 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 <1%
United Kingdom 2 <1%
Spain 2 <1%
Japan 2 <1%
China 1 <1%
Netherlands 1 <1%
France 1 <1%
Germany 1 <1%
Unknown 743 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 148 19%
Student > Master 136 18%
Student > Ph. D. Student 131 17%
Researcher 86 11%
Student > Doctoral Student 25 3%
Other 88 12%
Unknown 145 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 257 34%
Biochemistry, Genetics and Molecular Biology 255 34%
Immunology and Microbiology 19 3%
Medicine and Dentistry 15 2%
Chemistry 13 2%
Other 46 6%
Unknown 154 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#2,248,250
of 25,837,817 outputs
Outputs from Biology Direct
#81
of 541 outputs
Outputs of similar age
#10,259
of 130,769 outputs
Outputs of similar age from Biology Direct
#5
of 10 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 541 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,769 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.