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Mendeley readers
| Title |
U12 intron positions are more strongly conserved between animals and plants than U2 intron positions
|
|---|---|
| Published in |
Biology Direct, May 2008
|
| DOI | 10.1186/1745-6150-3-19 |
| Pubmed ID | |
| Authors |
Malay Kumar Basu, Wojciech Makalowski, Igor B Rogozin, Eugene V Koonin |
| Abstract |
We report that the positions of minor, U12 introns are conserved in orthologous genes from human and Arabidopsis to an even greater extent than the positions of the major, U2 introns. The U12 introns, especially, conserved ones are concentrated in 5'-portions of plant and animal genes, where the U12 to U2 conversions occurs preferentially in the 3'-portions of genes. These results are compatible with the hypothesis that the high level of conservation of U12 intron positions and their persistence in genomes despite the unidirectional U12 to U2 conversion are explained by the role of the slowly excised U12 introns in down-regulation of gene expression. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Sweden | 1 | 3% |
| Germany | 1 | 3% |
| Unknown | 37 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 30% |
| Student > Ph. D. Student | 8 | 20% |
| Student > Doctoral Student | 4 | 10% |
| Professor | 3 | 8% |
| Professor > Associate Professor | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 7 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 45% |
| Biochemistry, Genetics and Molecular Biology | 12 | 30% |
| Computer Science | 1 | 3% |
| Medicine and Dentistry | 1 | 3% |
| Engineering | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 7 | 18% |