Title |
Genomic analysis of an emerging multiresistant Staphylococcus aureusstrain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage
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Published in |
Biology Direct, January 2009
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DOI | 10.1186/1745-6150-4-1 |
Pubmed ID | |
Authors |
Jean-Marc Rolain, Patrice François, David Hernandez, Fadi Bittar, Hervé Richet, Ghislain Fournous, Yves Mattenberger, Emmanuelle Bosdure, Nathalie Stremler, Jean-Christophe Dubus, Jacques Sarles, Martine Reynaud-Gaubert, Stephanie Boniface, Jacques Schrenzel, Didier Raoult |
Abstract |
Staphylococcus aureus is a major human pathogen responsible for a variety of nosocomial and community-acquired infections. Recent reports show that the prevalence of Methicillin-Resistant S. aureus (MRSA) infections in cystic fibrosis (CF) patients is increasing. In 2006 in Marseille, France, we have detected an atypical MRSA strain with a specific antibiotic susceptibility profile and a unique growth phenotype. Because of the clinical importance of the spread of such strain among CF patients we decided to sequence the genome of one representative isolate (strain CF-Marseille) to compare this to the published genome sequences. We also conducted a retrospective epidemiological analysis on all S. aureus isolated from 2002 to 2007 in CF patients from our institution. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
United States | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 106 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 24 | 22% |
Researcher | 24 | 22% |
Professor > Associate Professor | 13 | 12% |
Student > Bachelor | 10 | 9% |
Student > Master | 9 | 8% |
Other | 17 | 15% |
Unknown | 13 | 12% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 17 | 15% |
Biochemistry, Genetics and Molecular Biology | 15 | 14% |
Immunology and Microbiology | 12 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 7 | 6% |
Unknown | 22 | 20% |