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Selection in spatial stochastic models of cancer: Migration as a key modulator of fitness

Overview of attention for article published in Biology Direct, April 2010
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Title
Selection in spatial stochastic models of cancer: Migration as a key modulator of fitness
Published in
Biology Direct, April 2010
DOI 10.1186/1745-6150-5-21
Pubmed ID
Authors

Craig J Thalhauser, John S Lowengrub, Dwayne Stupack, Natalia L Komarova

Abstract

We study the selection dynamics in a heterogeneous spatial colony of cells. We use two spatial generalizations of the Moran process, which include cell divisions, death and migration. In the first model, migration is included explicitly as movement to a proximal location. In the second, migration is implicit, through the varied ability of cell types to place their offspring a distance away, in response to another cell's death.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
France 2 3%
Switzerland 1 2%
Unknown 54 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 32%
Researcher 10 17%
Student > Master 7 12%
Professor 6 10%
Student > Doctoral Student 3 5%
Other 7 12%
Unknown 7 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 36%
Mathematics 10 17%
Physics and Astronomy 9 15%
Biochemistry, Genetics and Molecular Biology 3 5%
Sports and Recreations 3 5%
Other 6 10%
Unknown 7 12%