Title |
Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code
|
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Published in |
Biology Direct, December 2008
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DOI | 10.1186/1745-6150-3-53 |
Pubmed ID | |
Authors |
Harold S Bernhardt, Warren P Tate |
Abstract |
Transfer RNA (tRNA) is the means by which the cell translates DNA sequence into protein according to the rules of the genetic code. A credible proposition is that tRNA was formed from the duplication of an RNA hairpin half the length of the contemporary tRNA molecule, with the point at which the hairpins were joined marked by the canonical intron insertion position found today within tRNA genes. If these hairpins possessed a 3'-CCA terminus with different combinations of stem nucleotides (the ancestral operational RNA code), specific aminoacylation and perhaps participation in some form of noncoded protein synthesis might have occurred. However, the identity of the first tRNA and the initial steps in the origin of the genetic code remain elusive. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United Kingdom | 2 | 5% |
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Unknown | 36 | 92% |
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Researcher | 7 | 18% |
Professor > Associate Professor | 4 | 10% |
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Professor | 3 | 8% |
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Unknown | 4 | 10% |
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Chemical Engineering | 2 | 5% |
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