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A nitty-gritty aspect of correlation and network inference from gene expression data

Overview of attention for article published in Biology Direct, August 2008
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Title
A nitty-gritty aspect of correlation and network inference from gene expression data
Published in
Biology Direct, August 2008
DOI 10.1186/1745-6150-3-35
Pubmed ID
Authors

Lev B Klebanov, Andrei Yu Yakovlev

Abstract

All currently available methods of network/association inference from microarray gene expression measurements implicitly assume that such measurements represent the actual expression levels of different genes within each cell included in the biological sample under study. Contrary to this common belief, modern microarray technology produces signals aggregated over a random number of individual cells, a "nitty-gritty" aspect of such arrays, thereby causing a random effect that distorts the correlation structure of intra-cellular gene expression levels.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 4%
Norway 1 4%
United Kingdom 1 4%
Taiwan 1 4%
Argentina 1 4%
China 1 4%
United States 1 4%
Unknown 16 70%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 30%
Student > Master 5 22%
Student > Ph. D. Student 4 17%
Professor > Associate Professor 4 17%
Unspecified 1 4%
Other 1 4%
Unknown 1 4%
Readers by discipline Count As %
Computer Science 9 39%
Agricultural and Biological Sciences 9 39%
Biochemistry, Genetics and Molecular Biology 1 4%
Unspecified 1 4%
Chemistry 1 4%
Other 0 0%
Unknown 2 9%