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Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins

Overview of attention for article published in Biology Direct, October 2011
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Title
Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins
Published in
Biology Direct, October 2011
DOI 10.1186/1745-6150-6-57
Pubmed ID
Authors

Wing-Cheong Wong, Sebastian Maurer-Stroh, Frank Eisenhaber

Abstract

Sequence homology considerations widely used to transfer functional annotation to uncharacterized protein sequences require special precautions in the case of non-globular sequence segments including membrane-spanning stretches composed of non-polar residues. Simple, quantitative criteria are desirable for identifying transmembrane helices (TMs) that must be included into or should be excluded from start sequence segments in similarity searches aimed at finding distant homologues.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 4%
France 1 2%
Unknown 44 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 23%
Researcher 10 21%
Student > Master 5 11%
Professor > Associate Professor 4 9%
Professor 4 9%
Other 5 11%
Unknown 8 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 30%
Agricultural and Biological Sciences 12 26%
Chemistry 4 9%
Environmental Science 1 2%
Nursing and Health Professions 1 2%
Other 4 9%
Unknown 11 23%