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Mendeley readers
| Title |
cpRAS: a novel circularly permuted RAS-like GTPase domain with a highly scattered phylogenetic distribution
|
|---|---|
| Published in |
Biology Direct, May 2008
|
| DOI | 10.1186/1745-6150-3-21 |
| Pubmed ID | |
| Authors |
Marek Elias, Marian Novotny |
| Abstract |
A recent systematic survey suggested that the YRG (or YawG/YlqF) family with the G4-G5-G1-G2-G3 order of the conserved GTPase motifs represents the only possible circularly permuted variation of the canonical GTPase structure. Here we show that a different circularly permuted GTPase domain actually does exist, conforming to the pattern G3-G4-G5-G1-G2. The domain, dubbed cpRAS, is a variant of RAS family GTPases and occurs in two types of larger proteins, either inserted into a region homologous to a bacterial group of proteins classified as COG2373 and potentially related to the alpha-2-macroglobulin family (so far a single protein in Dictyostelium) or in combination with a von Willebrand factor type A (VWA) domain. For the latter protein type, which was found in a few metazoans and several distantly related protists, existence in the common ancestor of opisthokonts, Amoebozoa and excavates followed by at least eight independent losses may be inferred. Our findings thus bring further evidence for the importance of parallel reduction of ancestral complexity in the eukaryotic evolution. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 3% |
| Germany | 1 | 3% |
| South Africa | 1 | 3% |
| United Kingdom | 1 | 3% |
| Spain | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 23 | 79% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 38% |
| Student > Ph. D. Student | 7 | 24% |
| Student > Postgraduate | 2 | 7% |
| Professor > Associate Professor | 2 | 7% |
| Student > Master | 2 | 7% |
| Other | 5 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 66% |
| Biochemistry, Genetics and Molecular Biology | 7 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Physics and Astronomy | 1 | 3% |
| Chemistry | 1 | 3% |
| Other | 0 | 0% |