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Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage

Overview of attention for article published in Biology Direct, June 2006
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Title
Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage
Published in
Biology Direct, June 2006
DOI 10.1186/1745-6150-1-15
Pubmed ID
Authors

Adam Pavlicek, Jerzy Jurka

Abstract

Cernunnos-XLF is a nonhomologous end-joining factor that is mutated in patients with a rare immunodeficiency with microcephaly. Several other microcephaly-associated genes such as ASPM and microcephalin experienced recent adaptive evolution apparently linked to brain size expansion in humans. In this study we investigated whether Cernunnos-XLF experienced similar positive selection during human evolution.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 44%
Student > Ph. D. Student 5 28%
Lecturer 1 6%
Unknown 4 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 50%
Biochemistry, Genetics and Molecular Biology 4 22%
Chemistry 1 6%
Medicine and Dentistry 1 6%
Unknown 3 17%