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Mendeley readers
| Title |
The prokaryotic V4R domain is the likely ancestor of a key component of the eukaryotic vesicle transport system
|
|---|---|
| Published in |
Biology Direct, January 2008
|
| DOI | 10.1186/1745-6150-3-2 |
| Pubmed ID | |
| Authors |
Mircea Podar, Mark A Wall, Kira S Makarova, Eugene V Koonin |
| Abstract |
Intracellular vesicle traffic that enables delivery of proteins between the endoplasmic reticulum, Golgi and various endosomal subcompartments is one of the hallmarks of the eukaryotic cell. Its evolutionary history is not well understood but the process itself and the core vesicle traffic machinery are believed to be ancient. We show here that the 4-vinyl reductase (V4R) protein domain present in bacteria and archaea is homologous to the Bet3 subunit of the TRAPP1 vesicle-tethering complex that is conserved in all eukaryotes. This suggests, for the first time, a prokaryotic origin for one of the key eukaryotic trafficking proteins. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 8% |
| Germany | 2 | 5% |
| United Kingdom | 2 | 5% |
| Brazil | 1 | 3% |
| Russia | 1 | 3% |
| Argentina | 1 | 3% |
| Unknown | 30 | 75% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 28% |
| Professor | 8 | 20% |
| Student > Master | 5 | 13% |
| Student > Bachelor | 4 | 10% |
| Student > Ph. D. Student | 3 | 8% |
| Other | 4 | 10% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 57% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Medicine and Dentistry | 2 | 5% |
| Environmental Science | 1 | 3% |
| Chemical Engineering | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 6 | 15% |