Title |
MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival
|
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Published in |
Biology Direct, May 2011
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DOI | 10.1186/1745-6150-6-23 |
Pubmed ID | |
Authors |
Jianxiang Chi, Erica Ballabio, Xiao-He Chen, Rajko Kušec, Steve Taylor, Deborah Hay, Daniela Tramonti, Nigel J Saunders, Timothy Littlewood, Francesco Pezzella, Jacqueline Boultwood, James S Wainscoat, Christian SR Hatton, Charles H Lawrie |
Abstract |
MicroRNAs are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many cancers including hematological malignancies. However, the role of microRNAs in the pathogenesis of multiple myeloma (MM) is only poorly understood. We therefore used microarray analysis to elucidate the complete miRNome (miRBase version 13.0) of purified tumor (CD138+) cells from 33 patients with MM, 5 patients with monoclonal gammopathy of undetermined significance (MGUS) and 9 controls. |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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Student > Ph. D. Student | 16 | 18% |
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Other | 6 | 7% |
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