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Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells

Overview of attention for article published in Biology Direct, April 2010
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Title
Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells
Published in
Biology Direct, April 2010
DOI 10.1186/1745-6150-5-20
Pubmed ID
Authors

Zvia Agur, Yuri Kogan, Liora Levi, Hannah Harrison, Rebecca Lamb, Oleg U Kirnasovsky, Robert B Clarke

Abstract

The balance between self-renewal and differentiation of stem cells is expected to be tightly controlled in order to maintain tissue homeostasis throughout life, also in the face of environmental hazards. Theory, predicting that homeostasis is maintained by a negative feedback on stem cell proliferation, implies a Quorum Sensing mechanism in higher vertebrates.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
Malaysia 1 1%
Japan 1 1%
Russia 1 1%
Unknown 66 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 19%
Student > Ph. D. Student 13 18%
Professor > Associate Professor 10 14%
Student > Master 8 11%
Student > Bachelor 7 10%
Other 13 18%
Unknown 8 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 40%
Medicine and Dentistry 7 10%
Biochemistry, Genetics and Molecular Biology 7 10%
Engineering 5 7%
Physics and Astronomy 5 7%
Other 10 14%
Unknown 10 14%