Title |
A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico
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Published in |
Virology Journal, January 2013
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DOI | 10.1186/1743-422x-10-41 |
Pubmed ID | |
Authors |
Joel A Vazquez-Perez, Pavel Isa, Darwyn Kobasa, Christopher E Ormsby, Jose E Ramírez-Gonzalez, Damaris P Romero-Rodríguez, Charlene Ranadheera, Yan Li, Nathalie Bastien, Carissa Embury-Hyatt, Elizabeth González-Duran, Gisela Barrera-Badillo, Yuria Ablanedo-Terrazas, Edgar E Sevilla-Reyes, Marina Escalera-Zamudio, Ana G Cobián-Güemes, Irma Lopez, Joanna Ortiz-Alcántara, Celia Alpuche-Aranda, Jose R Perez-Padilla, Gustavo Reyes-Terán |
Abstract |
Pandemic type A (H1N1) influenza arose in early 2009, probably in Mexico and the United States, and reappeared in North America in September for seven more months. An amino acid substitution in the hemagglutinin (HA), D222G, has been reported in a significant proportion of patients with a severe and fatal outcome. We studied the prevalence of HA222 substitutions in patients in Mexico during the second wave and its association with clinical outcome and pathogenicity in a mouse model. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 22% |
Student > Bachelor | 8 | 16% |
Student > Master | 7 | 14% |
Student > Ph. D. Student | 5 | 10% |
Other | 3 | 6% |
Other | 7 | 14% |
Unknown | 10 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 25% |
Medicine and Dentistry | 9 | 18% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Immunology and Microbiology | 3 | 6% |
Business, Management and Accounting | 2 | 4% |
Other | 6 | 12% |
Unknown | 12 | 24% |