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Acidic extracellular microenvironment and cancer

Overview of attention for article published in Cancer Cell International, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 986)
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
1 news outlet
twitter
9 tweeters
patent
1 patent
video
3 video uploaders

Citations

dimensions_citation
660 Dimensions

Readers on

mendeley
817 Mendeley
citeulike
1 CiteULike
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Title
Acidic extracellular microenvironment and cancer
Published in
Cancer Cell International, January 2013
DOI 10.1186/1475-2867-13-89
Pubmed ID
Authors

Yasumasa Kato, Shigeyuki Ozawa, Chihiro Miyamoto, Yojiro Maehata, Atsuko Suzuki, Toyonobu Maeda, Yuh Baba

Abstract

Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being primarily considered to be due to lactate secretion from anaerobic glycolysis. Clinicopathological evidence shows that transporters and pumps contribute to H+ secretion, such as the Na+/H+ exchanger, the H+-lactate co-transporter, monocarboxylate transporters, and the proton pump (H+-ATPase); these may also be associated with tumor metastasis. An acidic extracellular pH not only activates secreted lysosomal enzymes that have an optimal pH in the acidic range, but induces the expression of certain genes of pro-metastatic factors through an intracellular signaling cascade that is different from hypoxia. In addition to lactate, CO2 from the pentose phosphate pathway is an alternative source of acidity, showing that hypoxia and extracellular acidity are, while being independent from each other, deeply associated with the cellular microenvironment. In this article, the importance of an acidic extracellular pH as a microenvironmental factor participating in tumor progression is reviewed.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 817 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 <1%
United Kingdom 2 <1%
South Africa 1 <1%
Italy 1 <1%
France 1 <1%
Germany 1 <1%
Slovakia 1 <1%
Canada 1 <1%
Spain 1 <1%
Other 1 <1%
Unknown 802 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 210 26%
Student > Master 125 15%
Student > Bachelor 121 15%
Researcher 95 12%
Student > Doctoral Student 49 6%
Other 108 13%
Unknown 109 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 136 17%
Chemistry 123 15%
Agricultural and Biological Sciences 109 13%
Medicine and Dentistry 77 9%
Engineering 58 7%
Other 178 22%
Unknown 136 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2021.
All research outputs
#1,159,067
of 17,464,602 outputs
Outputs from Cancer Cell International
#5
of 986 outputs
Outputs of similar age
#17,186
of 263,546 outputs
Outputs of similar age from Cancer Cell International
#3
of 31 outputs
Altmetric has tracked 17,464,602 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 986 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,546 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.