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Platelets, diabetes and myocardial ischemia/reperfusion injury

Overview of attention for article published in Cardiovascular Diabetology, May 2017
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Title
Platelets, diabetes and myocardial ischemia/reperfusion injury
Published in
Cardiovascular Diabetology, May 2017
DOI 10.1186/s12933-017-0550-6
Pubmed ID
Authors

Isabella Russo, Claudia Penna, Tiziana Musso, Jasmin Popara, Giuseppe Alloatti, Franco Cavalot, Pasquale Pagliaro

Abstract

Mechanisms underlying the pathogenesis of ischemia/reperfusion injury are particularly complex, multifactorial and highly interconnected. A complex and entangled interaction is also emerging between platelet function, antiplatelet drugs, coronary diseases and ischemia/reperfusion injury, especially in diabetic conditions. Here we briefly summarize features of antiplatelet therapy in type 2 diabetes (T2DM). We also treat the influence of T2DM on ischemia/reperfusion injury and how anti-platelet therapies affect post-ischemic myocardial damage through pleiotropic properties not related to their anti-aggregating effects. miRNA-based signature associated with T2DM and its cardiovascular disease complications are also briefly considered. Influence of anti-platelet therapies and different effects of healthy and diabetic platelets on ischemia/reperfusion injury need to be further clarified in order to enhance patient benefits from antiplatelet therapy and revascularization. Here we provide insight on the difficulty to reduce the cardiovascular risk in diabetic patients and report novel information on the cardioprotective role of widely used anti-aggregant drugs.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 77 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 12%
Student > Bachelor 9 12%
Student > Master 8 10%
Student > Ph. D. Student 7 9%
Student > Postgraduate 7 9%
Other 11 14%
Unknown 26 34%
Readers by discipline Count As %
Medicine and Dentistry 21 27%
Biochemistry, Genetics and Molecular Biology 8 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Agricultural and Biological Sciences 3 4%
Immunology and Microbiology 2 3%
Other 8 10%
Unknown 30 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2017.
All research outputs
#20,425,762
of 22,977,819 outputs
Outputs from Cardiovascular Diabetology
#1,233
of 1,396 outputs
Outputs of similar age
#275,476
of 316,427 outputs
Outputs of similar age from Cardiovascular Diabetology
#15
of 19 outputs
Altmetric has tracked 22,977,819 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,396 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,427 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.