Title |
Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection
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Published in |
Retrovirology, January 2014
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DOI | 10.1186/1742-4690-11-10 |
Pubmed ID | |
Authors |
Henri-Alexandre Michaud, Miguel de Mulder, Devi SenGupta, Steven G Deeks, Jeffrey N Martin, Christopher D Pilcher, Frederick M Hecht, Jonah B Sacha, Douglas F Nixon |
Abstract |
Human Endogenous Retroviruses (HERVs) comprise about 8% of the human genome and have lost their ability to replicate or to produce infectious particles after having accumulated mutations over time. We assessed the kinetics of expression of HERV-K (HML-2) Envelope mRNA transcript and surface unit (SU) and transmembrane (TM) subunit proteins during HIV-1 infection. We also mapped the specificity of the humoral response to HERV-K (HML-2) Envelope protein in HIV-1 infected subjects at different stages of disease, and correlated the response with plasma viral load. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 2% |
Canada | 1 | 2% |
Unknown | 57 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 19% |
Researcher | 8 | 14% |
Student > Bachelor | 8 | 14% |
Student > Master | 8 | 14% |
Professor > Associate Professor | 4 | 7% |
Other | 9 | 15% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 31% |
Biochemistry, Genetics and Molecular Biology | 13 | 22% |
Immunology and Microbiology | 8 | 14% |
Medicine and Dentistry | 4 | 7% |
Engineering | 3 | 5% |
Other | 2 | 3% |
Unknown | 11 | 19% |