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Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens

Overview of attention for article published in BMC Genomics, January 2014
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Title
Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens
Published in
BMC Genomics, January 2014
DOI 10.1186/1471-2164-15-82
Pubmed ID
Authors

Haoyang Cai, Nitin Kumar, Homayoun C Bagheri, Christian von Mering, Mark D Robinson, Michael Baudis

Abstract

Chromothripsis is a recently discovered phenomenon of genomic rearrangement, possibly arising during a single genome-shattering event. This could provide an alternative paradigm in cancer development, replacing the gradual accumulation of genomic changes with a "one-off" catastrophic event. However, the term has been used with varying operational definitions, with the minimal consensus being a large number of locally clustered copy number aberrations. The mechanisms underlying these chromothripsis-like patterns (CTLP) and their specific impact on tumorigenesis are still poorly understood.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Switzerland 1 1%
Unknown 93 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 22%
Student > Master 15 16%
Student > Ph. D. Student 11 12%
Student > Bachelor 8 8%
Student > Doctoral Student 6 6%
Other 14 15%
Unknown 20 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 32%
Agricultural and Biological Sciences 20 21%
Medicine and Dentistry 13 14%
Computer Science 6 6%
Chemistry 2 2%
Other 5 5%
Unknown 19 20%