Title |
In vitro antimicrosporidial activity of gold nanoparticles against Heterosporis saurida
|
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Published in |
BMC Veterinary Research, March 2016
|
DOI | 10.1186/s12917-016-0668-x |
Pubmed ID | |
Authors |
Mona Saleh, Gokhlesh Kumar, Abdel-Azeem Abdel-Baki, Saleh Al-Quraishy, Mansour El-Matbouli |
Abstract |
Worldwide, there is a need to expand the number of drugs available to treat parasitic infections in aquaculture. One of the new materials being tested is metal nanoparticles, which have unique chemical and physical characteristics owing to their extremely small size and high surface area to volume ratio. We examined the effectiveness of gold nanoparticles against the microsporidian parasite Heterosporis saurida, which causes severe economic losses in lizard fish, Saurida undosquamis aquaculture. We synthesized gold nanoparticles by chemical reduction of tetrachloroauric acid as a metal precursor. We assessed the antimicrosporidial efficacy of the nanoparticles against H. saurida using an in vitro screening approach, which we had developed previously using the eel kidney cell line EK-1. The number of H. saurida spores produced in EK-1 cells was reduced in a proportional manner to the dosage of gold nanoparticles administered. A cell metabolic activity test (MTT) indicated that the gold nanoparticles did not appear to be toxic to the host cells. Gold nanoparticles can act as an effective antimicrosporidial agent and hold promise to reduce disease in lizardfish aquaculture. Metal nanoparticles should be considered as an alternate choice for development of new antimicrosporidial drugs to combat disease problems in aquaculture. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 21% |
Student > Master | 5 | 13% |
Researcher | 4 | 11% |
Lecturer | 3 | 8% |
Student > Doctoral Student | 2 | 5% |
Other | 7 | 18% |
Unknown | 9 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 26% |
Veterinary Science and Veterinary Medicine | 5 | 13% |
Medicine and Dentistry | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Environmental Science | 2 | 5% |
Other | 7 | 18% |
Unknown | 9 | 24% |