Title |
The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials
|
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Published in |
BMC Neurology, June 2017
|
DOI | 10.1186/s12883-017-0885-3 |
Pubmed ID | |
Authors |
Jia-Jie Mo, Lin-Ying Liu, Wei-Bin Peng, Jie Rao, Zhou Liu, Li-Li Cui |
Abstract |
The effectiveness of creatine in treating Parkinson's disease (PD) has not been conclusively determined. Therefore, we performed a meta-analysis to address this issue. The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were searched, and outcomes measured by the Total Unified Parkinson's Disease Rating Scale (UPDRS) and the Schwab & England Scale were analyzed. Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis. There were no significant differences between the control and treatment groups in the total, mental, activities of daily living (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed. Creatine has no observed benefit in PD patients, although more correlated studies are still needed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 40% |
Luxembourg | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 17% |
Student > Ph. D. Student | 6 | 13% |
Researcher | 4 | 9% |
Student > Postgraduate | 4 | 9% |
Student > Master | 4 | 9% |
Other | 5 | 11% |
Unknown | 15 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 17% |
Nursing and Health Professions | 6 | 13% |
Neuroscience | 6 | 13% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Chemistry | 2 | 4% |
Other | 5 | 11% |
Unknown | 15 | 33% |