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Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

Overview of attention for article published in Acta Neuropathologica Communications, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

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2 X users
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1 patent
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1 Facebook page

Citations

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200 Dimensions

Readers on

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281 Mendeley
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Title
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
Published in
Acta Neuropathologica Communications, January 2014
DOI 10.1186/2051-5960-2-14
Pubmed ID
Authors

Simon Dujardin, Katia Lécolle, Raphaëlle Caillierez, Séverine Bégard, Nadège Zommer, Cédrick Lachaud, Sébastien Carrier, Noëlle Dufour, Gwennaëlle Aurégan, Joris Winderickx, Philippe Hantraye, Nicole Déglon, Morvane Colin, Luc Buée

Abstract

In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration have been well established in Alzheimer's disease (AD) and other sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy but the molecular and cellular mechanisms supporting this progression are yet not known. These pathways appear to be associated with the intercellular transmission of pathology, as recently suggested in Tau transgenic mice. However, these conclusions remain ill-defined due to a lack of toxicity data and difficulties associated with the use of mutant Tau.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 4 1%
United Kingdom 2 <1%
United States 1 <1%
Spain 1 <1%
Unknown 273 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 70 25%
Researcher 43 15%
Student > Master 41 15%
Student > Bachelor 26 9%
Student > Doctoral Student 16 6%
Other 40 14%
Unknown 45 16%
Readers by discipline Count As %
Neuroscience 77 27%
Agricultural and Biological Sciences 66 23%
Biochemistry, Genetics and Molecular Biology 32 11%
Medicine and Dentistry 20 7%
Chemistry 8 3%
Other 23 8%
Unknown 55 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2018.
All research outputs
#6,085,663
of 22,741,406 outputs
Outputs from Acta Neuropathologica Communications
#891
of 1,369 outputs
Outputs of similar age
#72,259
of 307,435 outputs
Outputs of similar age from Acta Neuropathologica Communications
#13
of 40 outputs
Altmetric has tracked 22,741,406 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,435 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.