Title |
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
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Published in |
Acta Neuropathologica Communications, January 2014
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DOI | 10.1186/2051-5960-2-14 |
Pubmed ID | |
Authors |
Simon Dujardin, Katia Lécolle, Raphaëlle Caillierez, Séverine Bégard, Nadège Zommer, Cédrick Lachaud, Sébastien Carrier, Noëlle Dufour, Gwennaëlle Aurégan, Joris Winderickx, Philippe Hantraye, Nicole Déglon, Morvane Colin, Luc Buée |
Abstract |
In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration have been well established in Alzheimer's disease (AD) and other sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy but the molecular and cellular mechanisms supporting this progression are yet not known. These pathways appear to be associated with the intercellular transmission of pathology, as recently suggested in Tau transgenic mice. However, these conclusions remain ill-defined due to a lack of toxicity data and difficulties associated with the use of mutant Tau. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 4 | 1% |
United Kingdom | 2 | <1% |
United States | 1 | <1% |
Spain | 1 | <1% |
Unknown | 273 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 70 | 25% |
Researcher | 43 | 15% |
Student > Master | 41 | 15% |
Student > Bachelor | 26 | 9% |
Student > Doctoral Student | 16 | 6% |
Other | 40 | 14% |
Unknown | 45 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 77 | 27% |
Agricultural and Biological Sciences | 66 | 23% |
Biochemistry, Genetics and Molecular Biology | 32 | 11% |
Medicine and Dentistry | 20 | 7% |
Chemistry | 8 | 3% |
Other | 23 | 8% |
Unknown | 55 | 20% |