Title |
Incomplete ileus and hemafecia as the presenting features of multi-organ involved primary systemic AL amyloidosis: a rare case report
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Published in |
BMC Gastroenterology, June 2017
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DOI | 10.1186/s12876-017-0628-3 |
Pubmed ID | |
Authors |
Li Tian, Anliu Tang, Xian Zhang, Zhen Mei, Fen Liu, Jingbo Li, Xiayu Li, Feiyan Ai, Xiaoyan Wang, Shourong Shen |
Abstract |
AL Amyloidosis is known to be a systemic disease affecting multiple organs and tissue while it's rare that patients present with gastrointestinal symptoms at first and later develop multiple-organ dysfuction. Clinical signs are not specific and the diagnosis is rarely given before performing immunofixation and endoscopy with multiple biopsies. We would like to emphasize the value of precise diagnostic process of AL amyloidosis. In this case report, we describe a 56-year-old man who presented with recurrent periumbilical pain for 4 months and gradually worsened over a month. After a series of tests, he was finally diagnosed with primary systemic AL amyloidosis. He was treated with a chemotherapy regimen (Melphalan, dexamethasone and thalidomide) achieving a good clinical response. On account of the high misdiagnosis rate, establishing the most precise diagnosis in first time with typing amyloidogenic protein becomes increasingly vital. Although the presenting feature is usually nonspecific, AL amyloidosis ought to be considered when multiple organs are involved in a short period. |
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Geographical breakdown
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 30% |
Student > Master | 2 | 20% |
Lecturer > Senior Lecturer | 1 | 10% |
Other | 1 | 10% |
Unknown | 3 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 40% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 10% |
Computer Science | 1 | 10% |
Nursing and Health Professions | 1 | 10% |
Unknown | 3 | 30% |