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Mendeley readers
Attention Score in Context
| Title |
Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells
|
|---|---|
| Published in |
Journal of Experimental & Clinical Cancer Research, February 2009
|
| DOI | 10.1186/1756-9966-28-28 |
| Pubmed ID | |
| Authors |
Kyoung-Ok Hong, Ji-Hong Kim, Ji-Soo Hong, Hye-Jung Yoon, Jae-Il Lee, Sam-Pyo Hong, Seong-Doo Hong |
| Abstract |
The Akt/PKB family of kinases is frequently activated in human cancers, including oral squamous cell carcinoma (OSCC). Akt-induced epithelial-to-mesenchymal transition (EMT) involves downregulation of E-cadherin, which appears to result from upregulation of the transcription repressor Snail. Recently, it was proposed that carcinoma cells, especially in metastatic sites, could acquire the mesenchymal-to-epithelial reverting transition (MErT) in order to adapt the microenvironments and re-expression of E-cadherin be a critical indicator of MErT. However, the precise mechanism and biologic or clinical importance of the MErT in cancers have been little known. This study aimed to investigate whether Akt inhibition would restore the expression of E-cadherin and beta-catenin, reduce that of Vimentin, and induce the MErT in OSCC cells with low or negative expression of E-cadherin. We also investigate whether inhibition of Akt activity would affect the E-cadherin repressors and signaling molecules like NF-kappaB, ERK, and p38. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Portugal | 1 | 1% |
| China | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 82 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 26% |
| Researcher | 18 | 21% |
| Student > Master | 12 | 14% |
| Student > Bachelor | 7 | 8% |
| Professor > Associate Professor | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 11 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 40% |
| Biochemistry, Genetics and Molecular Biology | 18 | 21% |
| Medicine and Dentistry | 13 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Chemistry | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 14 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2014.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#1,247
of 2,379 outputs
Outputs of similar age
#93,536
of 109,210 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#11
of 13 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,379 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,210 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.