Title |
Defense against HSV-1 in a murine model is mediated by iNOS and orchestrated by the activation of TLR2 and TLR9 in trigeminal ganglia
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Published in |
Journal of Neuroinflammation, January 2014
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DOI | 10.1186/1742-2094-11-20 |
Pubmed ID | |
Authors |
Guilherme Pimenta Zolini, Graciela Kunrath Lima, Natália Lucinda, Mariana Almeida Silva, Marcela França Dias, Natália Lima Pessoa, Bruna Pizziolo Coura, Christiane Teixeira Cartelle, Rosa Maria Esteves Arantes, Erna Geessien Kroon, Marco Antônio Campos |
Abstract |
Herpes simplex 1 (HSV-1) causes various human clinical manifestations, ranging from simple cold sores to encephalitis. Innate immune cells recognize pathogens through Toll-like receptors (TLRs), thus initiating the immune response. Previously, we demonstrated that the immune response against HSV-1 is dependent on TLR2 and TLR9 expression and on IFN gamma production in the trigeminal ganglia (TG) of infected mice. In this work, we further investigated the cells, molecules, and mechanisms of HSV-1 infection control, especially those that are TLR-dependent. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 22% |
Student > Master | 9 | 15% |
Student > Doctoral Student | 6 | 10% |
Student > Ph. D. Student | 6 | 10% |
Professor > Associate Professor | 4 | 7% |
Other | 11 | 19% |
Unknown | 10 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 20% |
Immunology and Microbiology | 10 | 17% |
Medicine and Dentistry | 10 | 17% |
Neuroscience | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 5 | 8% |
Unknown | 15 | 25% |